Cart
sales@molnova.com
Home - Products - Angiogenesis - c-Met/HGFR - SRI 31215

SRI 31215

CAS No. 1832686-44-8

SRI 31215( —— )

Catalog No. M20215 CAS No. 1832686-44-8

SRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 79 In Stock
5MG 132 In Stock
10MG 205 In Stock
25MG 413 In Stock
50MG 617 In Stock
100MG 879 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SRI 31215
  • Note
    Research use only, not for human use.
  • Brief Description
    SRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM.
  • Description
    SRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM
  • In Vitro
    Western Blot Analysis Cell Line:DU145 cells Concentration:10 μM Incubation Time:30 min Result:Prevented fibroblast-induced MET activation and signaling in tumor cells, but did not prevent MET activation induced by active HGF.Cell Migration Assay Cell Line:DU145 cells Concentration:10 μM Incubation Time:24 h Result:Did not interfere with HGF-induced migration, but inhibited fibroblast-induced migration of DU145 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    c-Met/HGFR
  • Recptor
    HGFA|matriptase|hepsin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1832686-44-8
  • Formula Weight
    533.6
  • Molecular Formula
    C27H34F3N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(C1)c1cccc(c1)C(N)=N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Owusu BY et al. Inhibition of pro-HGF activation by SRI31215 a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AMG-337

    AMG-337 is a potent and selective inhibitor of MET with biochemical IC50 of 1 nM; inhibits of HGF-mediated MET phosphorylation in PC3 cells.

  • c-Met inhibitor 1

    c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer.

  • Terevalefim

    Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.

Sign In Join Free